Sr Staff Software Program Manager, NPI (NGS)
Job Description
What if the work you did every day could impact the lives of people you know Or all of humanity
At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.
Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.
Senior Staff Software Program Manager, NPI (NGS)
Illumina is seeking a Senior Staff Software Program Manager to lead the software program for a new sequencing instrument. This role focuses on driving software development activities across the New Product Introduction (NPI) development cycle - from concept and architecture through verification, validation, launch, and transition to onmarket support.
The ideal candidate brings strong experience in software development lifecycles (SDLC) and product development processes (PDP), along with a background in instrumentation, embedded systems, and regulated product development. Familiarity with various sequencing technologies and medical device design controls is highly preferred.
Responsibilities
At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.
Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.
Senior Staff Software Program Manager, NPI (NGS)
Illumina is seeking a Senior Staff Software Program Manager to lead the software program for a new sequencing instrument. This role focuses on driving software development activities across the New Product Introduction (NPI) development cycle - from concept and architecture through verification, validation, launch, and transition to onmarket support.
The ideal candidate brings strong experience in software development lifecycles (SDLC) and product development processes (PDP), along with a background in instrumentation, embedded systems, and regulated product development. Familiarity with various sequencing technologies and medical device design controls is highly preferred.
Responsibilities
- Leading Instrument Software Workstreams throughout the NPI lifecycle, developing executable project plans, defining scope & goals, establishing WBS, and driving task ownership across engineering teams.
- Develop and manage detailed software schedules, resource plans, dependencies, and critical path analyses to ensure program milestones are achieved.
- Drive systemlevel integration planning for firmware, control software, data pipelines, cloud services, and user interfaces.
- Form and lead crossfunctional software extended teams, including by not limited to technical product management, system engineering, embedded systems, cloud, and test engineering.
- Identify program risks early and implement mitigation strategies; develop and track software KPIs and health indicators.
- Partner closely with Systems, Hardware, and Advanced Science teams to ensure alignment between workflows and instrument software design.
- Deliver regular updates to senior leadership on progress, risks, and crossfunctional alignment throughout the NPI phase.
- Work with software development, DevOps, software quality and support teams to deliver and ensure timely all software deliverables.
- Champion continuous improvement initiatives in software processes, tooling, and execution discipline across the NPI portfolio.
- Proven experience in product development lifecycle and NPI program management.
- Experience managing software development projects including SW releases, environment management, and embedded FW/SW development.
- Strong working knowledge of SCRUM, SAFe, Kanban, waterfall, or hybrid models.
- Advanced proficiency with Smartsheet, Office Timeline, Jira, and Confluence.
- Experience in regulated industry with understanding of design controls (21 CFR 820.30, ISO 13485:2016, ISO 14971:2019, IEC 62304:2006).
- Familiarity with NGS workflows, data analysis, and sequencing instrumentation.
- Bachelor's or Master's Degree (Computer Science/Engineering, Software/Electrical Engineering), with at least 15 years of MNC working experience in a regulated industry on product development (preferably on Medical Devices).
- More than 10 years as a software project manager
- PMP certification will be a plus.
More Info
Key Skills
Office Timeline
NGS workflows
regulated product development
sequencing instrumentation

